ManuSec 2025: Building Cyber Resilience Across Manufacturing

The 10th Annual ManuSec USA Summit once again proved why it remains the premier cybersecurity conference dedicated to the manufacturing sector. Over two days of strategy, collaboration, and innovation, the event brought together 150+ IT and OT security professionals from North America’s leading Aerospace, Defense, Automotive, Food & Beverage, Machinery, Electrical, Metals, Chemical, and Pharma industries. 

Hosted in a climate of growing digital risk, ManuSec USA 2025 offered a space for leaders to address one shared goal — protecting manufacturing operations from increasingly complex cyber threats while maintaining productivity, safety, and business continuity. 

A Conference of Strategy, Insight, and Leadership   

Across the two-day summit, participants explored new frameworks for securing operational technology (OT), managing cyber risk, and building stronger bridges between IT and OT teams. 

Key sessions highlighted the critical role of leadership, collaboration, and foundational security practices in strengthening cyber resilience. 

• Crisis Leadership stressed that effective response and communication during incidents can define careers. 

• Remote Access emphasized collaboration with individual sites to prevent unauthorized access. 

• Offensive Security urged organizations to establish strong asset management and visibility before advancing to complex defenses. 

• OT Threat Detection revealed that most operational threats first appear in IT systems, reinforcing the need for integrated monitoring and early detection. 

DeNexus at ManuSec: Quantifying Cyber Risk in Financial Terms 

Donovan from DeNexus led an insightful session on “Real-World, Actionable Uses of Financial Cyber Risk Quantification in Manufacturing.” 

His presentation demonstrated how data-driven, actuarial models can translate cyber risk into financial metrics that executives and boards can understand — enabling manufacturers to: 

• Justify OT cybersecurity investments with measurable ROI. 

• Prioritize mitigation projects and vulnerabilities based on financial impact. 

• Quantify risk exposure for board reporting and compliance. 

• Prepare for cyber insurance discussions with accurate loss modeling.   

By integrating DeRISK™ Cyber Risk Quantification (CRQ) and QVM solutions, manufacturing organizations can turn cybersecurity into a strategic business advantage — empowering leaders to defend budgets, right-size controls, and make informed, risk-aware decisions. 

Looking Ahead 

As cyber-physical systems continue to evolve, so must the strategies that protect them. Events like ManuSec USA are critical in shaping the next generation of industrial cybersecurity leaders — fostering collaboration between IT and OT professionals, sharing best practices, and advancing financial approaches to cyber resilience. 

DeNexus remains committed to helping manufacturers quantify, manage, and communicate cyber risk in financial terms — ensuring security investments drive measurable business value. 

Ready to see how DeRISK™ CRQ and QVM can help your organization quantify and manage cyber risk?

Book a demo today and discover how to turn cybersecurity into measurable business value.